SupernaturalSam and Dean Winchester are not human, they're titans.
They believe because they have the physical appearance of man that they are mortal. But come on, how many times have these bastards gotten off the noose?
How many straight up gods have they seen and instantly taken the stance of "I'm going to kill that bitch" Not trap, not banish, not incapacitate. Straight up murder. I think there's a reason these two haven't met Jehovah yet. Supernatural is the story of two Titans unleashed on the modern world. Maybe all hunters are Titans? And they just need to get the scent of something inhuman to drop their human "nice nice" and go into war mode?