Now, there is a possible sequel to all of our favorite game in the works. If you want, I can try and find the article. Anyways, what do you think a sequel would have for a story. At first I thought there wasn't anything to continue on, since the Aegis 7 "incident" was resolved. But then I got to thinking...there are still unanswered questions, like, why was CEC out at Aegis 7 in the first place? What drew them there, since the operation was illegal? Why did the government manufacture the parasite and the Red Marker? And most immediate upon everyone's mind, did Isaac Clarke survive? And is Nicole mutated, or just hallucinated at the end?
I think the beginning of the sequel, after that ending situation with the dead Nicole is "worked out," and assuming the game continues to follow Isaac, would have him land on a Unitologist mausoleum ship with the infection somewhere on his shuttle spreading through the ship. After fighting through that, he eventually makes it back to Earth, where the disease touches down with him, some (not all) people get infected in the area he lands in, and he has to fight them, military personnel trying to terminate him for what he knows, and uncovering the rest of the records of the incident as well as the government's creation of the Necromorphs, and the origin of the original Black Marker.